What is LADMEos2?
LADMEos2 is a case-based software for semi-mechanical in vitro-in vivo predictions. Through a simple and easy-to-follow graphical interface, LADMEos2 allows even a novice user to forecast the pharmacokinetics of drugs administered as oral formulations. This newly developed tool could be a valuable option for rapid screening of new products and their in vivo performance.
What kind of input data do you need?
Profiles from USP1, USP2, or PhysioCell apparatuses are required to describe in vitro drug dissolution, and dedicated template files enable easy data transfer. To ensure the most accurate dissolution conditions, we recommend using biopredictive media and test conditions. For pharmacokinetic simulations, parameters describing drug absorption, distribution (distribution volumes), and elimination (clearances) are necessary.
How does it work?
A modified Noyes-Whitney model is used for describing the dissolution process, and if two or more formulations are tested, LADMEos2 calculates the f2 similarity factor. Pharmacokinetic simulations are based either on classic compartmental models or population data. A distinct feature of LADMEos2 is the customized setup of gastric emptying kinetics. You may investigate how the first-order gastric emptying constant, the complete gastric emptying time, or the meal caloric value influences the time-concentration profile. In some cases, you may also choose the formulation type: tablet, capsule, granulate, or solution. Using non-compartmental methods, the software calculates the basic pharmacokinetic parameters (AUC, Cmax, and Tmax) based on the user-defined sampling schedule.
What are the software’s requirements?
LADMEos2 was written in Python, but the user operates it through a web browser. To simulate the pharmacokinetic profile, the user chooses one of the cases, depending on the drug solubility, the formulation type, the dissolution apparatus type, or the prandial state.
