We have adjusted our laboratory equipment and developed protocols for solubility and pharmaceutical formulation biopredictive dissolution testing in small scale, i.e. approx. 20 mL of medium. Our small scale dissolution setup is capable of maintaining constant conditions of temperature and stirring rate. We can provide real-time pH and temperature monitoring. The test could be performed in standard dissolution media (e.g. phosphate buffer), biorelevant media such as FaSSIF based on phosphate buffer or in combination with pHysio-grad® in bicarbonate buffer. The power of small scale allows not only API/formulation-saving testing but also predict performance of the formulation in clinical studies. Different pH protocols are available – constant pH, pH-step experiments or complex and pH multipoints programmes simulating GI tract known from standard scale testing (bicarbonate buffer only).