Publications

2021


Garbacz G., Zakowiecki D., Frankiewicz M., Hess T., Cal K., Gajda M., Dabrowska J., Kubiak B., Paszkowska J., Wiater M., Hoc D., Haznar-Garbacz D. Development of a Biphasic-Release Multiple-Unit Pellet System with Diclofenac Sodium Using Novel Calcium Phosphate-Based Starter Pellets.  Pharmaceutics. 2021 May 28;13(6):805 (PubMed)

Garbacz G., Juszczyk E., Kisło K., Żero P., Tratkiewicz E., Wieczorek M., Paszkowska J., Banach G., Wiater M., Hoc D., Sczodrok J., Danielak D. Development and Bio-Predictive Evaluation of Biopharmaceutical Properties of Sustained-Release Tablets with a Novel GPR40 Agonist for a First-in-Human Clinical Trial. Pharmaceutics. 2021 May 28;13(6):804 (PubMed)

2020



G. Garbacz, D. Danielak, G. Banach, J. Walaszczyk, M. Romanski, M. Bawiec, J. Paszkowska, M. Zielinska, J. Sczodrok, M. Wiater, D. Hoc, B. Kolodziej. A novel open source tool for ELISA result analysis. J Pharm Biomed Anal 2020 Sep 10;189:113415 (PubMed)

Garbacz G., Milanowski B., Hejduk A., Bawiec M., Jakubowska E., Urbańska A., Wiśniewska A., Lulek J. Biorelevant In Vitro Release Testing and In Vivo Study of Extended-Release Niacin Hydrophilic Matrix Tablets. AAPS PharmSciTech. 2020 Jan 27;21(3):83 (PubMed)

Garbacz G., Minecka A., Kamińska E., Tarnacka M., Jurkiewicz K., Talik A., Wolnica K., Dulski M., Kasprzycka A., Spychalska P., Kamiński K., Paluch M. Does the molecular mobility and flexibility of the saccharide ring affect the glass-forming ability of naproxen in binary mixtures? Eur J Pharm Sci. 2020 Jan 1;141:105091 (PubMed)

Garbacz G., Zakowiecki D., Frankiewicz M., Hess T., Cal K., Mikolaszek B., Paszkowska J., Wiater M., Hoc D. Preparation of delayed-release multiparticulate formulations of diclofenac sodium and evaluation of their dissolution characteristics using biorelevant dissolution methods. Journal of Drug Delivery Science and Technology 60:101986. (ResearchGate)

Garbacz G., Danielak D., Milanowski B., Wentowski K., Nogowska M., Katny M., Rogowsky P., Konwicki L., Puk E., Pieczuro J., Bawiec M., Lulek J. Physiologically Based Dissolution Testing in a Drug Development Process – a Case Study of a Successful Application in a Bioequivalence Study of Trazodone ER Formulations Under Fed Conditions. AAPS PharmSciTech 21(5). (ResearchGate)

Garbacz G., Maksym P., Tarnacka M., Heczko D., Knapik-Kowalczuk J., Mielanczyk A., Bernat R., Kaminski K., Paluch M. Pressure-assisted solvent- and catalyst-free production of well-defined poly(1-vinyl-2-pyrrolidone) for biomedical applications. RSC Advances 10(36):21593-21601. (ResearchGate)

Garbacz G., Wiater M., Hoc D., Paszkowska J. Hydrodynamics and mechanical stresses in pharmacopoeial and noncompendial dissolution testing. Farmacja Polska 76(4):210-221. (ResearchGate)

2019


Haznar-Garbacz, D., Garbacz, G, Weitschies, W.: Development of oral foams for topical treatment of inflammatory bowel disease. Journal of Drug Delivery Science and Technology, 2019, Volume 50: 287-292 (ScienceDirect)

Zakowiecki, D., Hess, T., Banach, G., Paszkowska, J., Garbacz, G.: Effect of intra- and extragranular addition of highly porous tribasic calcium phosphate on properties of immediate release acyclovir formulation – comparison with commercial tablets using compendial and biorelevant dissolution methods. Journal of Drug Delivery Science and Technology, 2019, Volume 51: 464-474 (ScienceDirect)

Garbacz G., Heczko D., Kaminska E., Tarnacka M., Jurkiewicz K., Dulski M., Bebenek A., Kaminski K., Paluch M. Varying thermodynamic conditions as a new way to tune the molecular order in glassy itraconazole. Journal of Molecular Liquids 286:110920. (ResearchGate)

2018


M. Grimm, M. Koziolek, M. Saleh, F. Schneider, G. Garbacz, J.P. Kühn, W. Weitschies: Gastric Emptying and Small Bowel Water Content after Administration of Grapefruit Juice Compared to Water and Isocaloric Solutions of Glucose and Fructose: A Four-Way Crossover MRI Pilot Study in Healthy Subjects. Mol Pharm 2018 Feb 5;15(2):548-559 (PubMed)

Kozyra A., Mugheirbi N. A., Paluch K. J., Garbacz G., Tajber L.: Phase Diagrams of Polymer-Dispersed Liquid Crystal Systems of Itraconazole/Component Immiscibility Induced by Molecular Anisotropy. Mol Pharm 2018 Nov 5;15(11):5192-5206 (PubMed)

2017


M. Neumann, F. Schneider, M. Koziolek, G. Garbacz, W. Weitschies: A novel mechanical antrum model for the prediction of the gastroretentive potential of dosage forms. Int J Pharm 2017 Sep 15;530(1-2):63-70.
(PubMed)

D. Haznar-Garbacz, E. Kaminska, D. Zakowiecki, M. Lachmann, K. Kaminski, G. Garbacz, P. Dorożyński, P. Kulinowski: Melts of Octaacetyl Sucrose as Oral-Modified Release Dosage Forms for Delivery of Poorly Soluble Compound in Stable Amorphous Form. AAPS PharmSciTech 2017 Feb;19(2):951-960
(PubMed)

2016


P. Kulinowski, K. Woyna-Orlewicz, J. Obrał, G. M. Rappen, D. Haznar-Garbacz, W. P. Węglarz, R. Jachowicz, G: Wyszogrodzka, J. Klaja, P. Dorożyński. Multimodal approach to characterization of hydrophilic matrices manufactured by wet and dry granulation or direct compression methods. Int J Pharm. 499 (2016) 263-270. (PubMed)

2015


D. Zakowiecki, K. Cal, K. Kaminski, K. Adrjanowicz, L. Swinder, E. Kaminska, G. Garbacz. The Improvement of the Dissolution Rate of Ziprasidone Free Base from Solid Oral Formulations. AAPS PharmSciTech. 16 (2015) 922-933. (PubMed)

G. Garbacz, G.-M. Rappen M. Koziolek, W. Weitschies. Dissolution of mesalazine modified release tablets under standard and bio-relevant test conditions. J. Pharm. Pharmacol. 67 (2015) 199-208. (PubMed)

M. Koziolek, M. Grimm, D. Becker, V. Iordanov, H. Zou, J. Shimizu, C. Wanke, G. Garbacz, W. Weitschies. Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap(®) System. J Pharm Sci.;104 (2015) 2855-2863. (PubMed)

P. Kulinowski, K. Woyna-Orlewicz, G.M. Rappen , D. Haznar-Garbacz, W. P. Węglarz, P. Dorożyński. An understanding of modified release matrix tablets behavior during drug dissolution as the key for prediction of pharmaceutical product performance – case study of multimodal characterization of quetiapine fumarate tablets. Int J Pharm. 484 (2015) 235-245.(PubMed)

2014


G. Garbacz, A. Kandzi, M. Koziolek, J. Mazgalski, W. Weitschies. Release Characteristics of Quetiapine Fumarate Extended Release Tablets Under Biorelevant Stress Test Conditions. AAPS Pharm. Sci. Tech. 15 (2014) 230-236. (PubMed)

M. Koziolek, K. Görke, M. Neumann, G. Garbacz, W. Weitschies. Development of a bio-relevant dissolution test device simulating mechanical aspects present in the fed stomach. Eur. J. Pharm. Sci. 57 (2014) 250-256. (PubMed)
G. Garbacz, D. Cadé, H. Benameur, W. Weitschies. Bio-relevant dissolution testing of hard capsules prepared from different shell materials using the dynamic open flow through test apparatus. Eur. J.Pharm. Sci. 57 (2014) 264-272. (PubMed)

G. Garbacz, B. Kołodziej, M. Koziolek, W. Weitschies, S. Klein. A dynamic system for the simulation of fasting luminal pH-gradients using hydrogen carbonate buffers for dissolution testing of ionisable compounds. Eur. J. Pharm. Sci. 51 (2014) 224-231. (PubMed)

L. Wilde, M. Bock, M. Wolf, G. Glöckl, G. Garbacz, W. Weitschies. Development of pressure-sensitive dosage forms with a core liquefying at body temperature. Eur. J. Pharm. Biopharm. 86 (2014) 507-513. (PubMed)

M. Koziolek, M. Grimm, G. Garbacz, J. P. Kühn, W. Weitschies. Intragastric volume changes after intake of a high-caloric, high-fat standard breakfast in healthy human subjects investigated by MRI. Mol. Pharm. 11 (2014) 1632-1639. (PubMed)

F. Eisenächer, G. Garbacz, K. Mäder. Physiological relevant in vitro evaluation of polymer coats for gastroretentive floating tablets. Eur. J. Pharm. Biopharm. 88 (2014) 778-786. (PubMed)

M. Drechsler, G. Garbacz, R. Thomann, R. Schubert. Development and evaluation of chitosan and chitosan/Kollicoat® Smartseal 30 D film-coated tablets for colon targeting. Eur. J. Pharm. Biopharm 88 (2014) 807-815. (PubMed)

2013


S.Klein, G. Garbacz, M. Pišlar, I. Locatelli, C. Liu, W. Weitschies, W. Siegmund, A. Mrhar, M. Bogataj. The role of individual gastric emptying of pellets in the prediction of diclofenac in vivo dissolution. J. Control. Release. 66 (2013) 286-293. (PubMed)

Garbacz, B. Kołodziej, M. Koziolek, W. Weitschies, S. Klein. An automated system for monitoring and regulating the pH of bicarbonate buffers. AAPS Pharm. Sci. Tech. 14 (2013)  517-522. (PubMed)

Koziolek, G. Garbacz, M. Neumann, W. Weitschies. Simulating the postprandial stomach: physiological considerations for dissolution and release testing. Mol. Pharm. 10 (2013) 1610-1622. (PubMed)

Koziolek, G. Garbacz, M. Neumann, W. Weitschies. Simulating the postprandial stomach: biorelevant test methods for the estimation of intragastric drug dissolution. Mol. Pharm. 10 (2013) 2211-2221. (PubMed)

Adrjanowicz, K. Kaminski, P. Wlodarczyk, K. Grzybowska, M. Tarnacka, D. Zakowiecki, G. Garbacz, M. Paluch and S. Jurga. Molecular dynamics of itraconazole at ambient and high pressure. Phys. Chem. Chem. Phys. 15 (2013) 20742-20752. (PubMed)

Adrjanowicz, K. Kaminski, P. Wlodarczyk, K. Grzybowska, M. Tarnacka, D. Zakowiecki, G. Garbacz, M. Paluch and S. Jurga. Molecular Dynamics of Supercooled Pharmaceutical Agent  Posaconazole Studied via Differential Scanning Calorimetry, Dielectric and Mechanical Spectroscopies. Mol. Pharm. 10 (2013) 3934-3945. (PubMed)

Wilde, M. Bock, G. Glöckl, G. Garbacz, W. Weitschies. Development of a pressure-sensitive glyceryl tristearate capsule filled with a drug-containing hydrogel. Int. J. Pharm. 461 (2013) 296-300. (PubMed)

2012


Garbacz and S. Klein. Dissolution testing of oral modified-release dosage forms. J. Pharm. Pharmacol. 64 (2012) 944-968. (PubMed)

Haznar-Garbacz, G. Garbacz, F. Eisenächer, Klein S, W. Weitschies. A novel liquefied gas based oral controlled release drug delivery system for liquid drug formulations. Eur. J. Pharm. Biopharm. 81 (2012) 334-338. (PubMed)

2011


D. Haznar-Garbacz, G. Garbacz, F. Eisenächer, Klein S, W. Weitschies. An oral-controlled release drug delivery system for liquid and semisolid drug formulations. AAPS Pharm. Sci. Tech. 4 (2011) 1183-1185. (PubMed)

2010


Garbacz, W. Weitschies, Investigation of dissolution characteristics of four diclofenac sodium extended release tablets using USP apparatus 2 and novel biorelevant dissolution stress test device. Drug. Dev. Ind. Pharm. 36 (2010) 518-530. (PubMed)

Garbacz, S. Klein, W. Weitschies. Dissolution stress test device – background and experiences. Expert Opin. Drug Deliv. 7 (2010) 1251-61. (PubMed)

2009


G. Garbacz, H. Blume, W. Weitschies, Investigation of the dissolution characteristics of six different nifedipine 20 mg extended release tablets using USP apparatus 2 and a novel dissolution test apparatus that mimics in vivo physical stress. Dissolution Technologies, 16 (2009) 7‒11.

G. Garbacz, U. Adam, B. Schug, H. Blume, W. Weitschies, Nifedipin-Retardtabletten mit unterschiedlicher Galenik. Deutsche Apotheker Zeitung 27 (2009) 70‒77.

M. Anschütz, G. Garbacz, O. Kosch, F. Donath, J. Wiedmann, W. Hoeckh, L. Trahms, B. Schug, W. Weitschies and H. Blume, Characterization of the behavior of alginate based microcapsules in vitro and in vivo. Int. J. Clin. Pharmacol. Ther. 47 (2009):556‒563. (PubMed)

G. Garbacz, B. Golke, R.-S. Wedemeyer, M. Sjöberg, E. Söderlind, B. Abrahamsson, W. Weitschies, Comparison of dissolution profiles obtained for nifedipine extended release once daily tablets using different dissolution test apparatuses. Eur. J. Pharm. Sci. 38 (2009) 147‒155. (PubMed)

2008


G. Garbacz, R.S. Wedemeyer, S. Nagel, T. Giessmann, H. Mönnikes, C.G. Wilson, W. Siegmund, W. Weitschies, Irregular absorption profiles observed from diclofenac extended release tablets can be predicted using a dissolution test apparatus that mimics in vivo physical stresses. Eur. J. Pharm. Biopharm. 70 (2008) 421–428. (PubMed)